Transglutaminases

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Also Known As:

Gamma-Glutamyltransferases, Glutaminyl-Peptide; Glutaminyl Peptide Gamma Glutamyltransferases; Protein Glutamine gamma Glutamyltransferases; gamma-Glutamyltransferases, Protein-Glutamine; Glutaminyl-Peptide Gamma-Glutamyltransferases; Protein-Glutamine gamma-Glutamyltransferases; Transglutaminase; Protein-glutamine:amine gamma-glutamyltransferase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Acyltransferases: 394
      - Aminoacyltransferases
        Transglutaminases: 1059

C Di Rosa Selected Research

C Di Rosa Research Topics

Disease

Drug/Important Bio-Agent (IBA)